This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

A schematic showing how R-loops, a hybrid of RNA and DNA, can form during DNA transcription when the messenger RNA chain being assembled by the RNA polymerase binds to one of the DNA strands. R-loops ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

MYC‑driven tumors silence innate immune alarms by clearing R‑loop–derived signals, exposing a new therapeutic angle for targeting MYC without broad inhibition.

Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

“There are currently limited therapeutic options for elderly patients with myeloid malignancies, who are ineligible for stem cell transplantation,” commented Dr. Sayantani Sinha, a postdoctoral ...

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA -- loops of DNA found outside of regular chromosomes -- are twice as ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...