Fluorescence labelling of an intracellular biomolecule in native living cells is a powerful strategy to achieve in-depth understanding of the biomolecule’s roles and functions. Besides being nontoxic ...

NUS chemists have developed a novel ratiometric fluorescent probe for studying cellular activity of the clinically important anticancer drug cisplatin for next generation drug development. Since its ...

Detecting problems with lysosomes is the focus of a new set of fluorescent probes. "A lot of diseases are related to problems with lysosome functions," says a chemistry doctoral candidate involved in ...

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is ...

Researchers at Cornell University are working on improving the trial-and-error process that is implicated in finding effective molecules for drug delivery ...

Probes used in life-cell fluorescence imaging must be able to penetrate cells and bind specifically to the protein of interest. Ideally, such probes also increase their fluorescence intensity when ...

Researchers are turning up the brightness on a group of fluorescent probes that are used to monitor biological activities of individual proteins in real-time. This latest advance enhances their ...

Chemists report a new fluorescent probe that glows only when bound to a membrane protein of interest (ACS Chem. Biol. 2014, DOI: 10.1021/cb400819c). The labeling method could help researchers track ...

A team of researchers led by Prof. Jiang Changlong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a fast and simple way to detect harmful pesticide ...

White blood cells act as the first line of defense in the immune system and are often referred to as an army that protects our body. Neutrophils account for the largest portion (55-70%) of white blood ...