A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...

Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here we present a combined ...

An ongoing challenge for researchers who are studying the origins of life is figuring out how biopolymers such as DNA and RNA might have formed in the first place. In the case of RNA, a candidate for ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

A team of US scientists has developed a new foundation model that can sift through genetic code across biology's five ...

The formation of 8,5′-cycloadenosine 5′-monophosphate (8,5′-cycloAMP) in irradiated solutions of adenosine 5′-monophosphate (5′-AMP) has been quantified over the pH range 2-10. Maxima for ...

Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism. DNA, which stands for deoxyribonucleic ...

A single process for how a group of molecules called nucleotides were made on the early Earth, before life began, has been suggested by a team of researchers. A single process for how a group of ...